(HUMAN CHORIONIC GONADOTROPIN)
Learn the secrets to health, hormones & nutrition.
- Maintain whole-body energy homeostasis
- Reduced hunger & food intake
- Increased fat metabolism
- Optimize or reduce the production of ghrelin
hCG is a hormone found in the female body during the early months of pregnancy. It is a glycoprotein hormone with a 92 amino acid α and a 145 amino acid β subunit. The β sub- unit confers specificity to the hormone and has an interesting set of conserved sequences that are similar to TGF-β. HCG’s role is to maintain the integrity of the corpus luteum of a pregnant woman’s ovary in order for her to produce the hormone progesterone, which is essential to her growing fetus. However, later studies of hCG suggested various metabolic activities throughout the body.
During 1950’s British endocrinologist by the name of A.T.W. Simeons discovered that the use of hCG when treating certain medical conditions also pro- moted weight loss at an accelerated rate. Later studies on the metabolic and weight loss biochemical function of hCG method suggested it as a complete program for the management of obesity. It contains pharmacologic, dietetic, and behavior mod- ifications through various signaling functions of hCG. But before going into the discussion of the multiple role of hCG into weight loss metabolism, it is important to explain and familiarize certain terms.
• BODY MASS INDEX (BMI)
• BASAL METABOLIC RATE (BMR)
• TYPES OF BODY FAT
• DIGESTIVE ENZYMES
BODY MASS INDEX (BMI)
The body mass index, or BMI, is a scale that provides an indication of your overall body composition and fat. It is a statistical measurement of a person’s body weight that is based on both weight and height. It is used to determine what a person’s ideal weight is. A person’s ideal BMI, for the most part, stays constant—as long as you are at one height, your ideal weight will always fall within a certain range. Actual BMI will change as you lose or gain weight and muscle.
• Normal BMI falls in the range of 18.5 to 24.9.
• BMI below 18.5 is underweight.
• BMI of 25 to 29.9 is overweight.
• BMI of 30 to 34.9 is obesity I, 35 to 39.9 is obesity II.
• BMI of 40 or more is obesity II, or morbid obesity.
Each BMI classification beyond normal is associated with a progressively increasing risk of cardiovascular disease, and morbid obesity may be a fatal condition.
BODY METABOLIC RATE (BMR)
BMR refers to the number of calories a person would burn in a day even if he or she did nothing but sit or lie in one place or the measure of the amount of energy your body requires to perform its normal vital functions at rest. Your BMR, however, will decrease as you age. As we get older, our metabolisms naturally slow, making it harder for us to eat whatever we want and still be skinny. Several factors go in to determining your BMR, including your age, sex, body composition and diet. Your BMR has the most significant impact on your body’s daily energy requirements, accounting for about 60 to 75 percent of your total metabolism. The frequency and type of food you eat accounts for about 10 to 20 percent, and your physical activity level accounts for 20 to 30 percent of your body’s daily energy needs. Your basal metabolic rate, or Your BMI and BMR are related in the sense that a larger body composition is generally associated with a higher BMR.
TYPES OF BODY FAT
Weight loss is intricately related to body fat or adipose reserves and its metabolism. Based on metabolic role and functions there were three types of fat or adipose tissues in the human body:
This “good fat” protects your major organs and joints; it is ordinarily NOT burned for energy. Resides around joints and organs to provide protection and support and also structural phospholipid in cell membranes.
ESSENTIAL FAT RESERVES:
Also “good fat,” this type of fat is evenly spread throughout your body to, ideally, be burned when your body needs immediate fuel. Or else day-to-day source of energy .
SECONDARY OR NON-ESSENTIAL STORED FAT:
Also called adipose fat, this type of fat is not needed and is what accumulates when a person becomes obese. It is stored underneath your skin and around your organs as a spare fuel supply, caus- ing those unsightly bumps and bulges. Your body makes this as a final survival strategy should you become malnourished. Accumulates around the hips, thighs, waist, stomach, buttocks and behind the upper arms (women) and upper chest, back and neck (men). These fats are not released during normal diet and exercise and retained as “emergency” reserves. Only released as a last resort in instances of calorie restriction or short/long term starvation. It is available to be burned during pregnancy or during periods of inadequate caloric intake.
USING BMI, BMR, AND TYPES OF FAT IN WEIGHTS LOSS METABOLISM
If you have a BMI that falls outside the normal range, you can use your BMR to accurately determine the number of calories you need to consume each day to either gain or lose weight. You need to accumulate a positive or negative energy balance of 3,500 calories to gain or lose 1 pound of fat. For example, if you have a BMI of 25 to 30, you are about 10 percent over your ideal weight. If you weigh 175 pounds and have a BMI of 25.1, your ideal weight is roughly 158 pounds, and you would need to accumulate a negative energy balance of 61,250 calories to reach this weight. Further, the loss of weight has to be ideally from secondary or non-essential stored fat.
HCG REGIME DIFFERENTIALLY METABOLIZE FAT FROM SECONDARY OR NON-ESSENTIAL STORED FAT
While treating certain people in Africa, Dr. Simeons noticed that those who consumed only 500-800 calories per day had controlled appetite and lost significant amounts of interior fat deposits (also known as visceral or organ fat). While a person who normally consumed such low calories would typically enter into “starvation mode,” a bodily condition that actually encourages the storage of fat, people receiving HCG seemed to simply become more fit. Today, advocates of the diet contend that daily HCG affects the signaling of the Hypothalamus in the brain to encourage fat burning instead of fat storing. It is also believed that this helps the body to maintain its muscle mass during the low calorie diet as well as decrease hunger.
HOW HCG REGULATES KEY ENERGY METABOLISM
1) hCG regulates the Leptin biochemical signaling Leptin is major energy metabolizing or balancing hormone. In obese peo- ple, the increased leptin from adipocytes induces a metabolic resistance. In leptin resistance, high leptin levels have diminished actions on the cell similar to that of low leptin levels. There are several proposed mechanisms for leptin resistance including leptin receptor dysfunction, impaired downstream signaling and inad- equate transport of leptin across the blood-brain-barrier (BBB) resulting in a de- crease in the cerebrospinal-fluid/serum leptin ratio. Leptin receptors are widely distributed in the human brain-including expression in the cortex, amygdala, hip- pocampus, and thalamus-with highest levels in hypothalamic nuclei such as the arcuate nucleus (ARC) and paraventricular nucleus (PVN). The earliest and most robust role of HCG Matrix leptin in the brain is its anorexigenic action in the hypothalamus. Leptin regulates feeding behavior and body weight homeostasis by inhibiting orexigenic neuropeptide Y (NPY) and stimulating anorexigenic proopiomelanocortin (POMC) neurons in the ARC, which project to the lateral hypothalamus and PVN. Decreased leptin levels that occur during fasting upregulate agoutirelated peptide (AgRP) in the hypothalamus, which increases food intake. Leptin also increases energy expenditure and thermogenesis by stimulating the sympathetic nervous system. In a congenital leptin deficient patient, leptin treatment decreased activation of the amygdala in response to pictures of food. This suggests that leptin regulates the emotional response to food.
Several studies have shown that hCG metabolize non-essential fat re- serves which induces transient increased production of leptin. Further, the hCG also modulates to increase the sensitiv- ity of the leptin by upregulating the key class of receptors, thereby obviating the negative effect of leptin resistance. hCG through the indirect action of leptin re- duce the food intake. Once the fat re- serves is depleted, the leptin level will also reduce via a feedback mechanism.
- Anorexigenic action in the Hypothalamus
- Decreased agoutirelated peptide
- Reduced hunger & food intake
- Increased fat metabolism and release
- Increased leptin
- Reduces leptin resistance
- Increases leptin transportation to brain
2) hCG regulates the Ghrelin biochemical signaling
Numerous studies have shown that hCG reduce or optimize the amount of ghrelin produced by different sets of tissue systems which will reduce the urge for food intake.
Ghrelin is a stomach hormone, secreted into the bloodstream that initiates food intake by activating NPY/AgRP neurons in the hypothalamic acruate nucleus. Ghrelin plays an important role in energy metabolism by regulating food intake, body weight and glucose homeostasis. Ghrelin is a metabolic hormone that promotes energy conservation by regulating appetite and energy expenditure. Although some studies suggest that antagonizing ghrelin function attenuates body weight gain and glucose intolerance on a high calorie diet, there is little information about the metabolic actions of ghrelin in the obese state.
Ghrelin’s ability to bind and activate ghrelin receptor (GRLN-R),that mediates neuroendocrine effects of this peptide. The abundant distribution of GRLN-R in the pituitary gland and hypothalamus may account for the important central effects of ghrelin.
In addition to its potent GH-releasing activity, this peptide is involved in the modulation of lactotropic, corticotropic, and gonadotropic axes. Interestingly, ghrelin also plays a pivotal role in energy homeostasis , being to date the only known peripheral orexigenic hormone. Primarily produced by the stomach in response to hunger and starvation, ghrelin serves as a humoral signal inform- ing brain centers about acute or chronic changes in peripheral energy balance. Apart from the stomach, which is certainly the major source of circulating lev- els of ghrelin, many peripheral tissues express both this peptide and its receptor.
Ghrelin is a 28 amino acid peptide presenting a unique n-octanoylation modification on its serine in position 3, catalyzed by ghrelin O-acyl transferase. Ghrelin is mainly produced by a subset of stomach cells and also by the hCG modulates ghrelin biochemical functions hypothalamus, the pituitary, and other tissues. Transcriptional, translational, and posttranslational processes generate ghrelin and ghrelin-related peptides. Homo- and heterodimers of growth hormone secretagogue receptor, and as yet unidentified receptors, are assumed to mediate the biological effects of acyl ghrelin and desacyl ghrelin, respectively. Ghrelin exerts wide physiological actions throughout the body, including growth hormone secretion, appetite and food intake, gastric secretion and gastro- intestinal motility, glucose homeostasis. Interestingly, weight loss restores ghrelin secretion and function, and we hypothesize that ghrelin resistance is a mechanism designed to protect a higher body weight set-point established during times of food availability, to maximize energy reserves during a time of food scarcity. Ghrelin primarily functions during negative energy balance to maintain whole-body energy homeostasis.
In addition to its potent GH-releasing activity, this peptide is involved in the modulation of lactotropic, corticotropic, and gonadotropic axes. Interesting- ly, ghrelin also plays a pivotal role in energy homeostasis, being to date the only known peripheral orexigenic hormone. Primarily produced by the stomach in response to hunger and starvation, ghrelin serves as a humoral signal informing brain centers about acute or chronic changes in peripheral energy balance. Apart from the stomach, which is certainly the major source of circulating levels of ghrelin, many peripheral tissues express both this peptide and its receptor.
Ghrelin is a 28 amino acid peptide presenting a unique n-octanoylation modification on its serine in position 3, catalyzed by ghrelin O-acyl transferase. Ghrelin is mainly produced by a subset of stomach cells and also by the hypo- thalamus, the pituitary, and other tissues. Transcriptional, translational, and post- translational processes generate ghrelin and ghrelin-related peptides. Homo- and heterodimers of growth hormone secretagogue receptor, and as yet unidentified receptors, are assumed to mediate the biological effects of acyl ghrelin and desacyl ghrelin, respectively.
Ghrelin exerts wide physiological actions throughout the body, including growth hormone secretion, appetite and food intake, gastric secretion and gastrointestinal motility, glucose homeostasis. Interestingly, weight loss restores ghrelin secretion and function, and we hypothesize that ghrelin resistance is a mechanism designed to protect a higher body weight set-point established during times of food availability, to maximize energy reserves during a time of food scarcity. Ghrelin primarily functions during negative energy balance to maintain whole-body energy homeostasis.
3) hCG regulates the Adiponectin biochemical signaling
hCG optimize the amount of adiponectin in circulation. Adiponectin is a peptidic hormone abundantly expressed in mature adipocytes that circulate in high concentrations in plasma. Adiponectin expression decreases in all 80 processes related to inflammation and insulin resistance such as obesity and diabetes 81 mellitus. Plasma adiponectin decreases before the onset of obesity and insulin resistance 82 in primates, suggesting that hypoadiponectinemia contributes to the pathogenesis of these 83 diseases. Adiponectin levels increase when insulin sensitivity improves, either due to the reduction in body weight or to treatment with insulin sensitizing drugs.
4) Adrenalin and stress hormone biochemical signaling
Some data suggest hCG has significant role in reducing the stress hor- mones in the circulation. The stress hormones are increased when your It is vital to health for the adrenals to secret more cortisol in response to stress. It is very important that bodily functions and cortisol levels return to normal following a stressful event. In high-stress culture and high chronic inflammatory conditions, the stress response is activated so often that the body does not always have a chance to return to normal. It leads to health problems resulting from too much circulating cortisol and/or from too little cortisol if the adrenal glands become chronically fatigued.
5) Optimize dicephalon functions
Diencephalon is rather a primitive part of the brain which is responsible for the basic functions of the body such as breathing and heartbeat. It also directs and optimize fat storage partitioning and its metabolic use. Disruption of signaling to diecephalon can be caused by various factors, including genetics, endocrine disorders and abrupt changes in either caloric intake or expenditure. hCG reset the signaling for an optimized metabolism of fat from non-essential fat reserves by differentially targeting various beta oxidation enzyme systems.
RECAP ON HCG
Human Chorionic Gonadatropin is a hormone produced in women during pregnancy that burns away fat from the mother’s body. While it’s role during pregnancy is to supply nutrition to the fetus, in the diet it simply helps to remove deep organ fat, or visceral fat.
Is this the drops?
NO. The drops were unregulated and often impotent. Many people were buying the drops of supposed HCG and not getting real results. Fortunately, the FDA recently banned the drops to ensure that counterfeits could no longer be distributed. Genuine HCG can only be obtained with a prescription from a licensed physician.
The HCG diet must be prescribed and supervised by a physician. Although preferences regarding specifics may vary slightly among physicians prescribing the program, the basic principles of the approach include a low calorie diet and the administration of HCG for 23-60 days. The diet is normally consists of a minimum of 500 and a maximum of 1800 calories per day with a dose of HCG from 125iu. The diet is rarely extended beyond 60 days, since the body builds up a resistance to HCG and should be permitted 3 to 4 months to reset before utilizing the diet again.
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